USPTO Patents Application 10561839

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(54) Title: DEVICE FOR MEASURING EXTRACELLULAR POTENTIAL, METHOD OF MEASURING EXTRACELLULAR
POTENTIAL BY USING THE SAME AND APPARATUS FOR QUICKLY SCREENING DRUG PROVIDED THEREWITH

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(57) Abstract: A device for measuring extracellular potential whereby a minor change in an electrical signal generated from a
biological sample can be easily and highly reliably detected. This device, whereby extracellular potential can be measured at a high
accuracy and a high output, is composed of at least

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one well which is formed on a substrate and provided with a means of holding cells, measuring electrode(s) for detecting the electrical
signal(s) of the respective well(s), and a standard electrode. The holding means comprises at least one cavity formed in the well which
has a through hole connected to a cell-sucking means on the bottom.

(57)

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INTERNATIONAL SEARCH REPORT

International application No.

PCT/JP02/00061

A. CLASSIFICATION OF SUBJECT MATTER

Int. CI 7 C12M1/34, C12Q1/02, G01N33/15, 33/48, 33/50, 27/28, 27/416

According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols)

Int. CI 7 C12M1/34, C12Q1/02, G01N33/48-33/98

Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched

Electronic data base consulted during the international search (name of data base and, where practicable, search terms used)
BIOSIS/MEDLINE/WPIDS (STN)
JICST ( JOIS)

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category*

Citation of document, with indication, where appropriate, of the relevant passages

Relevant to claim No.

P,X

WO, 01/25769, A2 ( Sophionbioscience AS),
12 April, 2001 (12.04.01),
& AU 200074065 A

1-38

X

WO, 99/31503, Al (Ecole Polyteqnic Federale
Lausanne) ,

24 June, 1999 (24.06.99),

& EP 1040349 Al & JP 2002-508516 A

1-38

A

WO, 99/66329, Al (Genes Ltd.),
23 December, 1999 (23.12.99),
& EP 1084410 Al

1-38

A

WO, 97/27318, Al (Matsushita Electric Ind Co . , Ltd.),
31 July, 1997 (31.07.97),
& EP 823483 A

1-38

A

JP, 9-289886, A (Shimadzu Corp.),
11 November, 1997 (11.11.97),
(Family: none)

1-38 ]

px] Further documents are listed in the continuation of Box C. See patent family annex.

* Special categories of cited documents: "T' later document published after the international filing date or
"A" document defining the general state of the art which is not priority date and not in conflict with the application but cited to

considered to be of particular relevance understand the principle or theory underlying the invention
"E" earlier document but published on or after the international filing "X" document of particular relevance; the claimed invention cannot be

date considered novel or cannot be considered to involve an inventive
"L" document which may throw doubts on priority claim(s) or which is step when the document is taken alone

cited to establish the publication date of another citation or other "Y" document of particular relevance; the claimed invention cannot be

special reason (as specified) considered to involve an inventive step when the document is
"O" document referring to an oral disclosure, use, exhibition or other combined with one or more other such documents, such

means combination being obvious to a person skilled in the art
"P" document published prior to the international filing date but later document member of the same patent family

than the priority date claimed

Date of the actual completion of the international search
04 April, 2002 (04.04.02)

Date of mailing of the international search report
16 April, 2002 (16.04.02)

Name and mailing address of the ISA/

Japanese Patent Office

Facsimile No.

Authorized officer
Telephone No.

Form PCT/ISA/210 (second sheet) (July 1998)

INTERNATIONAL SEARCH REPORT

International application No.

PCT/JP02/00061

C (Continuation). DOCUMENTS CONSIDERED TO BE RELEVANT

Category*

Citation of document, with indication, where appropriate, of the relevant passages

Relevant to claim No.

A

Masahiro OBARA et al., "Giga-Seal Kyuin Denkyoku no
Seisaku to Tan' itsu Shinkin Saibo eno Oyo", Ninon Seiri
Shi, 1983nen, 45, pages 629 to 639

1-38 i

Form PCT/ISA/210 (continuation of second sheet) (July 1998)

MmmSm^r PCT/JP0 2/0 0 0 6 1

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Int. CI 7 C12M1/34, C12Q1/02, G01N33/15, 33/48, 33/50, 27/28, 27/416

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Int. CI 7 C12M1/34, C12Q1/02, G01N33/48-33/98

. BIOSIS/MEDLINE/WPIDS (STN)
JICST (JOIS)

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WO 01/25769 A2 (S0PHI0NBI0SCIENCE AS)

2001. 04. 12

&AU 200074065 A

1-38

X

W0 99/31503 Al (EC0LE POLYTEQNIC FEDERALE LAUSANNE)
1999. 06. 24

&EP 1040349 Al &JP 2002-508516 A

1-38

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WO 99/66329 A 1 (GENES LIMITED)
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WO 97/27318 A 1 (MATSUSHITA ELECTRIC IND CO LTD)
1997. 07. 31
&EP 823483 A

JP 9-289886 A"
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